Simply put, synergy is that when two drugs are used i […]
Simply put, synergy is that when two drugs are used in combination, their efficacy will be stronger than when they are used alone.
Antagonism is that when the two drugs are used in combination, certain physical and chemical reactions will occur that reduce the efficacy or are completely ineffective, and there may be increased toxicity.
For example, the combination of copper sulfate and ferrous sulfate has a synergistic effect and its insecticidal effect will be more obvious, but the combination of copper sulfate and quicklime will have an antagonistic effect.
Because quicklime is an alkaline substance, and copper sulfate is slightly acidic, when they are used together, a neutralization reaction will occur, and the efficacy will be reduced or even invalid.
Most disinfectants are acidic, so they should not be combined with quicklime, such as chlorine dioxide, strong chlorin, bleaching powder, potassium permanganate, etc.
Quicklime cannot be used with trichlorfon in particular, because the two substances mixed together will produce more toxic dichlorvos, which is very easy to cause poisoning and death.
Common synergistic effects include: combination of penicillin, hydrogen peroxide and glacial acetic acid, rhubarb and ammonia, etc. Common antagonistic effects include fluoperic acid (norfloxacin) and chloramphenicol, rifampicin, tetracyclines Drugs such as oxytetracycline and penicillin.
Frequent dressing changes
Many fishery drugs may have more dead fish the next day after use. This is because some old, weak, sick and disabled fish, especially fish with severe symptoms, are stimulated by the drug.
It’s the reason why the fish will die faster because of the reaction, so it is normal for the fish to increase the next day after the medication.
At this point, fishermen’s friends should know a little bit. In fact, the occurrence of fish diseases also has certain stages, which can be divided into infection period, outbreak period and decline period.
Therefore, fish disease treatment is divided into a certain course of treatment. If a parasitic disease occurs, usually 1 to 2 days as a course of treatment can achieve the purpose of treatment.
In the event of bacterial or viral diseases, it takes 3 to 5 days as a course of treatment, so if the dead fish gradually reduce their food intake and return to normal after 3 days of medication, the medicine is effective.
If there is no improvement, the disease will become more and more serious before the drug is determined to be ineffective, and the symptoms should be re-diagnosed and replaced with other drugs.
Just as some people are allergic to certain drugs, some fish are also very sensitive to certain drugs, even a small dose can cause death.
Common famous and high-quality aquatic product medication taboos include: mandarin fish is sensitive to trichlorfon and copper chloride and should not be used; snakehead snakehead is very sensitive to ferrous sulfate and should be banned.
Freshwater white pomfret is forbidden to sense trichlorfon; California seabass is more sensitive to trichlorfon and should be used with caution; prawns are more sensitive to methamidophos and trichlorfon and should be used with caution, especially sensitive to enemy killing should be prohibited;
Roche prawns are sensitive to trichlorfon and should be banned; frogs cannot survive in 1‰ salt water, so frogs should pay special attention to the salt content. The majority of fishermen should keep in mind the above drug taboos to avoid unnecessary losses.
High temperature medication
Most fishermen believe that: the higher the temperature, the stronger the effect, and the faster and better the treatment effect. We emphasize that the time to spray drugs in ponds should generally be 8-9 in the morning or 3-5 in the afternoon, and no medicine is generally used at noon.
This is because when the temperature exceeds 38°C, the fish stop eating, and the liquid medicine volatilizes faster. If the medicine is used at noon in the hot season, not only will it not be effective in preventing fish diseases, but it will cause fish poisoning.
Most drugs become more toxic with increasing temperature, especially insecticidal drugs, such as copper sulfate. In the range of 16~30℃, every 5℃ increase in water temperature will increase the efficacy of 85%~90%.
The potassium permanganate aqueous solution is unstable and decomposes when exposed to light, forming manganese dioxide precipitation. Iodine preparations are volatile at high temperatures.
Insecticides are more targeted. For example, trichodes use copper sulfate and ferrous sulfate, ringworms use mebendazole, and fish needles use cypermethrin.
After long-term use, the parasites have developed a strong resistance to them, and if you want to kill them, you must continue to increase the amount.
Take copper sulfate as an example. It has a small safety range and an overdose will cause fish to float. However, using the same amount today has no effect at all.